Journal
FEBS LETTERS
Volume 580, Issue 1, Pages 41-45Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2005.11.044
Keywords
angiotensin II; bioluminescence resonance energy transfer; endocytosis; internalization; receptor regulation
Funding
- Wellcome Trust Funding Source: Medline
Ask authors/readers for more resources
Agonist stimulation of G protein-coupled receptors causes receptor activation, phosphorylation, P-arrestin binding and receptor internalization. Angiotensin II (AngII) causes rapid internalization of the AT, receptors, whereas AngII-bound AT(2) receptors do not internalize. Although the activation of the rat AT(1A) receptor with AngII causes translocation of beta-arrestin2 to the receptor, no association of this molecule with the AT(2) receptor can be detected after AngII treatment with confocal microscopy or bioluminescence resonance energy transfer. These data demonstrate that the two subtypes of angiotensin receptors have different mechanisms of regulation. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available