Journal
FEBS LETTERS
Volume 580, Issue 1, Pages 239-244Publisher
WILEY
DOI: 10.1016/j.febslet.2005.12.004
Keywords
pannexin; purinergic receptor; activation by calcium; ATP-induced ATP release; calcium wave
Funding
- NIGMS NIH HHS [GM48610] Funding Source: Medline
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The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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