Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 49, Issue 1, Pages 31-34Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm051060o
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- Intramural NIH HHS [Z01 AI000693-15] Funding Source: Medline
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A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC99 = 0.19 mu M) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.
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