Journal
NEUROIMAGE
Volume 29, Issue 2, Pages 662-666Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2005.07.038
Keywords
dopamine receptors; first-episode psychosis; outcome; premorbid adaptation; schizophrenia; SPECT
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In a preliminary 123I-IBZM SPECT study in first-episode psychosis, a relationship between striatal dopaminergic D2 receptor (D2R) binding and premorbid adjustment was suggested. These results were replicated in the present study (it = 18), and D2R binding at diagnosis predicted a high probability for schizophrenia outcome by 2-year follow-up. The present findings contribute to the evidence of abnormal D2R binding in schizophrenia and suggest that SPECT might be useful for outcome prediction in first-episode psychosis. (c) 2005 Elsevier Inc. All rights reserved.
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