Journal
BIOSENSORS & BIOELECTRONICS
Volume 21, Issue 7, Pages 1359-1364Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2005.06.006
Keywords
optical fiber; image guide; pH sensor; imaging; biosensor; microjet; inkjet; microdot
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We demonstrate the feasibility of using Drop-on-Demand microjet printing technology for fabricating imaging sensors by reproducibly printing an array of photopolymerizable sensing elements, containing a pH sensitive indicator, on the surface of an optical fiber image guide. The reproducibility of the microjet printing process is excellent for microdot (i.e. micrometer-sized polymer) sensor diameter (92.2 +/- 2.2 mu m), height (35.0 +/- 1.0 mu m), and roundness (0.00072 +/- 0.00023). pH sensors were evaluated in terms of pH sensing ability (<= 2% sensor variation), response time, and hysteresis using a custom fluorescence imaging system. In addition, the microjet technique has distinct advantages over other fabrication methods, which are discussed in detail. (c) 2005 Published by Elsevier B.V.
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