Journal
NEUROSCIENCE LETTERS
Volume 392, Issue 3, Pages 159-164Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.09.054
Keywords
nucleus accumbens; pain; aversion; fMRI
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Funding
- PHS HHS [012581, 13650] Funding Source: Medline
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Using functional magnetic resonance imaging (fMRI) we found that a noxious thermal stimulus (46 degrees C) to the hand activates the nucleus accumbens (NAc) in humans, while a non-noxious warm stimulus (41 degrees C) does not. Following the noxious stimulus, two distinct foci of decreased activation were observed showing distinct time course profiles. One focus was anterior, superior, and lateral and the second that was more posterior, inferior, and medial. The anatomical segregation may correlate with the functional components of the NAc, i.e., shell and core. The results support heterogeneity of function within the NAc and have implications for the understanding the contribution of NAc function to processing of pain and analgesia. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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