Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 3, Pages 538-542Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0507171102
Keywords
pressure measurement; microcirculation; hemolysis; red blood cell; membrane properties
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We propose a broadly applicable high-speed microfluiclic approach for measuring dynamical pressure-drop variations along a micrometer-sized channel and illustrate the potential of the technique by presenting measurements of the additional pressure drop produced at the scale of individual flowing cells. The influence of drug-modified mechanical properties of the cell membrane is shown. Finally, single hemolysis events during flow are recorded simultaneously with the critical pressure drop for the rupture of the membrane. This scale-independent measurement approach can be applied to any dynamical process or event that changes the hydrodynamic resistance of micro- or nanochannels.
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