Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 3, Pages 1057-1060Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4177-05.2006
Keywords
alcohol; ocular dominance plasticity; visual development; ferret; monocular deprivation; optical imaging; neocortex development; fetal alcohol syndrome
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Funding
- PHS HHS [013023-05A1] Funding Source: Medline
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Although some studies showed the efficacy of phosphodiesterase (PDE) inhibitors as neuronal plasticity enhancers, little is known about the effectiveness of these drugs to improve plasticity in cases of mental retardation. Fetal alcohol syndrome (FAS) is the leading cause of mental retardation in the western world. Using a combination of electrophysiological and optical imaging techniques, we show here that vinpocetine, a PDE type I inhibitor, restores ocular dominance plasticity in the ferret model of fetal alcohol exposure. Our finding should contribute to a better understanding and treatment of cognitive deficits associated with mental disorders, such as FAS.
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