4.7 Article

Cladobotric acids A-F:: New cytotoxic polyketides from a New Zealand Cladobotryum sp.

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 2, Pages 492-497

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo051883l

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Cladobotric acids A-F (1-6), fungal-derived polyketides, were isolated from the fermentation broth of a New Zealand Cladobotryum species. Structures were determined by extensive spectral analysis and X-ray crystallography, and the polyketide origin of 1-6 was concluded from feeding experiments with C-13-labeled precursors. The observed folding pattern for the polyketide chain is unusual for fungi. Cladobotric acids A-F (1-6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans.

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