Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 238, Issue 2, Pages 257-268Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2005.05.017
Keywords
metabolism; glycogen phosphorylase; creatine kinase; calcium; compartmentation
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This manuscript discusses aspects of functional compartmentation in the regulation of metabolism. The functional consequences of enzymes coupling between creatine kinase.. glycogen phosphorylase and sarcoplasmic reticular Ca(2+) ATPase is examined. It is proposed that the coupling of creatine kinase and glycogen phosphorylase classifies as a novel class of diazyme complex with an important regulatory role in the inhibition of glycogenolysis at rest. In addition it is suggested that creatine kinase, glycogen phosphorylase and the sarcoplasmic reticular Ca(2+) ATPase may couple to form a three-enzyme complex. From a consideration of the structure and chemical catalysis of the Putative three-enzyme complex, a novel net reaction for glycogenolysis in file vicinity of the sarcoplasmic reticulum is suggested (Phosphocreatine +Glycogen+ H(+) -Creatine +Glycogen(n-1)+ Glucose-1-Phosphate). The three-enzyme complex may also have an important role in inhibiting glycogenolysis at rest as well as improving the efficiency of high-energy phosphate transfer. (c) 2005 Elsevier Ltd. All rights reserved.
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