Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 203, Issue 1, Pages 141-152Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20050390
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Funding
- NIAID NIH HHS [R44 AI051045, R43 AI051045] Funding Source: Medline
- NIGMS NIH HHS [P50 GM52585, P50 GM052585] Funding Source: Medline
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Reperfusion injury ( RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.
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