Journal
FEBS LETTERS
Volume 580, Issue 2, Pages 497-504Publisher
WILEY
DOI: 10.1016/j.febslet.2005.12.049
Keywords
NOX1; NADPH oxidase; blood pressure; angiotensin II; extraacellular matrix
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To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure. In response to angiotensin 11 they showed an almost complete loss of the sustained blood pressure response, while the initial increase was conserved. NOXI-deficient mice showed a marked reduction in aortic media hypertrophy. Angiotensin II-induced smooth muscle cell proliferation was conserved, but there was a marked decrease in extracellular matrix accumulation. Our results establish a role for NOX1 in blood pressure regulation and vascular angiotensin 11 response. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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