Journal
FEBS LETTERS
Volume 580, Issue 2, Pages 393-398Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2005.11.084
Keywords
canonical Wnt signaling; beta-catenin; reporter hormone-inducible; transgenesis; Xenopus laevis
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The canonical Wnt pathway is recurrently used during embryogenesis and adult life. To track the cellular output of Wnt signaling in a living organism, we designed a hormone-inducible Wnt responsive system, capable to dynamically and specifically report Wnt pathway activities through eGFP expression. In contrast to previous in vivo reporters, our system essentially avoids interference of consecutive signals by remaining dormant until addition of hormone, which makes it a valuable tool to map canonical Wnt signaling in post-embryonic stages. Transgenic Xenopus laevis embryos were analyzed revealing at tadpole stage in specific tissues and organs cell populations with high Wnt pathway activity. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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