Journal
FEBS LETTERS
Volume 580, Issue 2, Pages 463-468Publisher
WILEY
DOI: 10.1016/j.febslet.2005.12.042
Keywords
calcium; endoplasmic reticulum; stores; quantal release; fluxes
Ask authors/readers for more resources
Physiological regulation of Ca2+ release from the endoplasmic reticulum (ER) is critical for cell function. Recent direct measurements of free [Ca2+] inside the ER ([Ca2+](ER)) revealed that [Ca2+](ER) itself is a key regulator of ER Ca2+ handling. However, the role of this new regulatory process in generating various patterns of Ca2+ release remains to be elucidated in detail. Here, we incorporate the recently quantified experimental correlations between [Ca2+](ER) and Ca2+ movements across the ER membrane into a mathematical model ER Ca2+ handling. The model reproduces basic experimental dynamics of [Ca2+](ER). Although this was not goal in model design, the model also exhibits mechanistically unclear experimental phenomena such as quantal Ca2+ release, and store charging by increasing resting cytosolic [Ca2+]. While more complex explanations cannot be ruled out, on the basis of our data we propose that quantal release and store charging could be simple re-equilibration phenomena, predicted by the recently quantified biophysical dynamics of Ca2+ movements across the ER membrane. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available