Journal
TETRAHEDRON LETTERS
Volume 47, Issue 4, Pages 473-475Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.11.061
Keywords
biosynthesis; indolocarbazole; staurosporine; chromopyrrolic acid; StaD; RebD; VioB; indole-3-pyruvic acid; heme
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Indole-3-pyruvic acid was transformed to chromopyrrolic acid by a novel heme-containing enzyme StaD responsible for staurosporine biosynthetic pathway in Streptomyces sp. TP-A0274. (c) 2005 Elsevier Ltd. All rights reserved.
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