Journal
CURRENT BIOLOGY
Volume 16, Issue 2, Pages 140-149Publisher
CELL PRESS
DOI: 10.1016/j.cub.2005.11.068
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Funding
- Medical Research Council [MC_U122673973, MC_U122669938] Funding Source: Medline
- MRC [MC_U122673973, MC_U122669938] Funding Source: UKRI
- Medical Research Council [MC_U122669938, MC_U122673973] Funding Source: researchfish
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Background: In a specialized epithelial cell such as the Drosophila photoreceptor, a conserved set of proteins is essential for the establishment of polarity, its maintenance, or both-in Drosophila, these proteins include the apical factors Bazooka, D-atypical protein kinase C, and D-Par6 together with D-Ecadherin. However, little is known about the mechanisms by which such apical factors might regulate the differentiation of the apical membrane into functional domains such as an apical-most stack of microvilli or more lateral sub-apical membrane. Results: We show that in photoreceptors; Bazooka (D-Par3) recruits the tumor suppressor lipid phosphatase PTEN to developing cell-cell junctions (Zonula Adherens, za). za-localized PTEN controls the spatially restricted accumulation of optimum levels of the lipid PtdIns(3,4,5)P3 within the apical membrane domain. This in turn finely tunes activation of Akt1, a process essential for proper morphogenesis of the light-gathering organelle, consisting of a stack of F-actin rich microvilli within the apical membrane. Conclusions: Spatially localized PtdIns(3,4,5)P3 mediates directional sensing during neutrophil and Dictyostelium chemotaxis. We conclude that a conserved mechanism also operates during photoreceptor epithelial cell morphogenesis in order to achieve normal differentiation of the apical membrane.
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