Journal
NEUROLOGY
Volume 66, Issue 2, Pages 265-267Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000194316.91908.8a
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The authors calculated the progression rate (Delta FS) using the total revised ALS Functional Rating Scale (ALSFRS-R) and symptom duration at diagnosis in 82 Japanese patients with ALS. Survival (death or tracheostomy) differed significantly with the Delta FS and postdiagnostic period according to log-rank testing, but Cox proportional hazards modeling revealed no strong association between total ALSFRS-R and mortality, suggesting that the Delta FS provides an additional predictive index beyond ALSFRS-R alone.
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