Journal
NEUROLOGY
Volume 66, Issue 2, Pages 250-252Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000194318.74946.b6
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Funding
- NCCIH NIH HHS [AT00613] Funding Source: Medline
- NCRR NIH HHS [M01-RR01066, M01-RR00645] Funding Source: Medline
- NINDS NIH HHS [NS35255, NS042861] Funding Source: Medline
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In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2=-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.
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