Journal
SENSORS AND ACTUATORS A-PHYSICAL
Volume 126, Issue 1, Pages 98-106Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.sna.2005.10.001
Keywords
spin valve sensor; GMR; magnetic nanoparticle; biodetection; biosensor
Funding
- NHGRI NIH HHS [P01 HG000205, P01 HG000205-090004] Funding Source: Medline
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We present giant magnetoresistance (GMR) spin valve sensors designed for detection of superparamagnetic nanoparticles as potential biomolecular labels in magnetic biodetection technology. We discuss the sensor design and experimentally demonstrate that as few as similar to 23 monodisperse 16-nm superparamagnetic Fe3O4 nanoparticles can be detected by submicron spin valve sensors at room temperature without resorting to lock-in detection. A patterned self-assembly method of nanoparticles, based on a polymer-mediated process and fine lithography, is developed for the detection. It is found that sensor signal increases linearly with the number of nanoparticles. (C) 2005 Elsevier B.V. All rights reserved.
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