Journal
SCIENCE
Volume 311, Issue 5760, Pages 531-535Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1118995
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Funding
- NCI NIH HHS [R01 CA081000] Funding Source: Medline
- NIGMS NIH HHS [R01 GM075922, R01 GM063919-07, R01 GM063919-08, R01 GM075922-04, R01 GM063919] Funding Source: Medline
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The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytosketetat matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.
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