Journal
CANCER LETTERS
Volume 232, Issue 1, Pages 70-78Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.07.040
Keywords
chromatin structure; fragile sites; FRAXA; FRA3B; FRA16B
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Funding
- NCI NIH HHS [CA85826] Funding Source: Medline
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Cytological appearance of fragile sites as non-staining gaps in metaphase chromosomes suggests an abnormality in chromatin structure. Studies of fragile sites at three levels of chromosome organization: (1) examining the ability of DNA derived from fragile sites to form nucleosomes-the basic structural element of chromosomes, (2) probing the arrangement of nucleosome arrays over fragile sites in fragile site-expressing cell lines, and (3) visualizing fragile sites in higher-order chromatin organization, reveal an unusual chromatin structure associated with fragile sites. This fragile site-associated chromatin structure might play an active role in DNA metabolic processes such as replication, transcription, repair and recombination, which are closely linked to the instability of fragile sites. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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