Journal
VACCINE
Volume 24, Issue 5, Pages 691-695Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2005.08.009
Keywords
tuberculosis vaccine; mucosal delivery; transgenic plants
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Funding
- NIAID NIH HHS [5R03-AI-055285, N01-AI-40091] Funding Source: Medline
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Transgenic plants are a novel way to produce and deliver oral vaccines. Arabidopsis thaliana material shown previously to express the tuberculosis (TB) antigen ESAT-6 fused to the B subunit of Escherichia coli heat-labile enterotoxin (LTB) was fed to mice and the resulting immune response investigated. The plant-made LTB-ESAT-6 fusion protein induced antigen-specific responses from CD4+ cells and increased IFN-gamma production, indicating a Th1 response. In addition, a Th2 response was induced in the Peyer's patch. This is the first report of an orally delivered, subunit, tuberculosis vaccine priming an antigen-specific, Th1 response. (c) 2005 Elsevier Ltd. All rights reserved.
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