Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 146, Issue 1, Pages 43-51Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2005.09.007
Keywords
magnetic resonance imaging; functional; depressive disorder; major
Categories
Funding
- NCRR NIH HHS [M01RR00827, M01 RR000827-328412, M01 RR000827] Funding Source: Medline
- NIMH NIH HHS [5 K08 MH01642, K08 MH001642, K08 MH001642-05] Funding Source: Medline
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This study used functional MRI (fMRI) to clarify the sites of brain activity associated with the antidepressant effects of sleep deprivation (SD). We hypothesized: (1) baseline perfusion in right and left amygdalae will be greater in responders than in nonresponders; (2) following partial sleep deprivation (PSD), perfusion in responders' right and left amygdalae would decrease. Seventeen unmedicated outpatients with current major depression and eight controls received perfusion-weighted fMRI and structural MRI at baseline and following 1 night of late-night PSD. Baseline bilateral amygdalar perfusion was greater in responders than nonresponders. Clusters involving both amygdalae decreased from baseline to PSD specifically in responders. Right amygdalar perfusion diverged with PSD, increasing in nonresponders and decreasing in responders. These novel amygdalar findings are consistent with the overarousal hypothesis of SD as well as other functional imaging studies showing increased baseline amygdalar activity in depression and decreased amygdalar activity with remission or antidepressant medications. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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