Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 5, Pages 1283-1288Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0510511103
Keywords
human bone marrow; nonhematopoietic; stem/progenitor cells; ischemia
Categories
Funding
- NHLBI NIH HHS [HL 073252, P01 HL 07561, R01 HL073252, HL 073755, R01 HL073755] Funding Source: Medline
- NIAMS NIH HHS [AR 48323, R01 AR048323] Funding Source: Medline
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Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential roles in aging and determining lifespan. A variety of heritable and acquired diseases are linked to mitochondrial dysfunction. We report here that mitochondria are more dynamic than previously considered: mitochondria or mtDNA can move between cells. The active transfer from adult stem cells and somatic cells can rescue aerobic respiration in mammalian cells with nonfunctional mitochondria.
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