Journal
CLINICAL IMMUNOLOGY
Volume 118, Issue 2-3, Pages 300-306Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2005.09.019
Keywords
plasmacytoid dendritic cells; glucocorticoid; interferon-alpha; Toll-like receptor; apoptosis; differentiation
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Funding
- NIAID NIH HHS [AI 41011, AI 60994] Funding Source: Medline
- NIDDK NIH HHS [DK 49745] Funding Source: Medline
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Plasmacytoid dendritic cells (pDC) are an important source of type-1 interferon (IFN) following microbial infection and also play key roles in the induction of innate and adaptive immune responses. Here, we show that the glucocorticoid (GC) dexamethasone (Dex) strikingly reduces pDC (and myeloid DC) numbers in secondary lymphoid tissue and liver of normal and hematopoietic growth factor-mobilized mice and suppresses pDC differentiation from bone marrow precursors in vitro. Moreover, the apoptotic death of pDC in vitro was enhanced by exposure to Dex. Notably, however, Toll-like receptor 9 expression and virally induced IFN alpha production by residual pDC from Dex-treated animals were unaffected. Thus, whereas marked reduction in absolute numbers of pDC by GC may predispose to viral infection, often associated with GC-mediated immuno suppression, reductions in pDC and IFN alpha production may contribute to the beneficial effects on GC observed in systemic autoimmune disease, in which that both pDC and IFN alpha have been implicated. alpha 2005 Elsevier Inc. All rights reserved.
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