Inhibition of Candida parapsilosis mitochondrial respiratory pathways enhances susceptibility to caspofungin

Among the Candida species, Candida parapsilosis has a unique mitochondrial respiratory network. The addition of inhibitors of the respiratory pathways in three clinical isolates of C. parapsilosis with high (>= 2-mu g/ml) MICs of caspofungin significantly (fivefold) decreased caspofungin MICs but did not change fluconazole MICs.