Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 4, Pages 2069-2072Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.80.4.2069-2072.2006
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Funding
- NHLBI NIH HHS [R37 HL038180, R01 HL038180] Funding Source: Medline
- NIAID NIH HHS [AI-25903, U01 AI025903] Funding Source: Medline
- NIDDK NIH HHS [R01 DK056260, P30 DK052574, P30 DK056341, P30 DK056341-06] Funding Source: Medline
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APOBEC3F and APOBEC3G (hA3F and hA3G) are part of an innate mechanism of antiretroviral defense. The human immunodeficiency virus type 1(HIV-1) accessory protein Vif targets both proteins for proteasomal degradation. Using mRNA from peripheral blood mononuclear cells of 92 HIV-infected subjects not taking antiretroviral therapy and 19 HIV-uninfected controls, we found that hA3F (P < 0.001) and hA3G (P = 0.016) mRNA levels were lower in HI-infected subjects and were positively correlated with one another (P = 0.003). However, we found no correlation in the abundance of either hA3F or hA3G mRNA with either viral load or CD4 counts in HIV-infected subjects.
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