Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 41, Issue 2, Pages 208-212Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2005.11.001
Keywords
Coumarin; antibacterial activity; anti-Helicobacter pylori activity
Categories
Ask authors/readers for more resources
In order to develop new anti-Helicobacter pylori agents, five new and three already known N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides (coumarin-3-carboxamides) were prepared and evaluated for their antibacterial activity. All synthesized compounds showed little or no activity against different species of Gram-positive and Gram-negative bacteria of clinical relevance and against various strains of pathogenic fungi. Among the prepared compounds those with a 4-acyl-phenyl group showed the best activity against H. pylori metronidazole resistant strains in the 0.25-1 mu g/ml MIC range, indicating the presence of an acyl function as an important feature for activity. (c) 2005 Elsevier SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available