Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 3, Pages 1584-1587Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.80.3.1584-1587.2006
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI 07614, T32 AI007614] Funding Source: Medline
- NIGMS NIH HHS [R29 GM 56406, R29 GM056406] Funding Source: Medline
Ask authors/readers for more resources
The papillomavirus (PV) E1 helicase plays a direct role in recruiting cellular DNA replication factors, such as replication protein A or polymerase alpha-primase, to replicate PV genomes. Here, E1 is shown to bind to human topoisomerase I and stimulate its relaxation activity up to sevenfold. The interaction between E1 and topoisomerase I was mapped to the E1 DNA binding domain and C terminus. These findings imply a mechanism for the recruitment of topoisomerase I to PV DNA replication forks and for stimulating topoisomerase I to allow for efficient relaxation of the torsional stress induced by replication fork progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available