Journal
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
Volume 134, Issue 2, Pages 245-249Publisher
MOSBY, INC
DOI: 10.1016/j.otohns.2005.11.016
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OBJECTIVE: The aim of this study was to evaluate the effects of Staphlylococcus aureus exotoxin B (SE-B) on proinflammatory cytokine/chemokine releases in primary nasal epithelial cell cultures (NECC) of subjects with and without chronic rhinosinusitis (CRS). STUDY DESIGN AND SETTING: NECC (CRS: n = 14; Controls: n = 11) were stimulated with SE-B. Protein concentrations of interleukin-(IL-1 beta, IL-6, and IL-8 levels were measured in NECC supernatants by ELISA before (TO) and after 24 hr stimulation with SE-B (TI). RESULTS: TO: supernatants of the NECC of CRS patients contained significant lower levels of IL-8 (2.1 ng/ml) compared to Controls (IL-8: 6.2 ng/ml; P < 0.01). TI: SE-B induced a significant increase of IL-6 in NECC (P < 0.001). IL-1 beta was not detectable. CONCLUSIONS: This is the first study evaluating the effects of exotoxins on NECC. SE-B showed proinflammatory effects on NECC. SIGNIFICANCE: Our data Suggest that resident NECC are involved in immunological responses to Staphylococcus aureus toxins, supplementing the so-called superantigen hypothesis in CRS. (c) 2006 American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc. All rights reserved.
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