Journal
EXPERT REVIEW OF PROTEOMICS
Volume 3, Issue 1, Pages 97-110Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.3.1.97
Keywords
continuous infusion; flooding dose; mass isotopomer distribution analysis (MIDA); mass spectrometry; protein turnover; proteomics; radioisotopes; stable isotopes
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Funding
- Biotechnology and Biological Sciences Research Council [BB/C507510/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/C507510/1] Funding Source: Medline
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Protein turnover is a neglected dimension in postgenomic studies, defining the dynamics of changes in protein expression and forging a link between transcriptome, proteome and metabolome. Recent advances in postgenomic technologies have led to the development of new proteomic techniques to measure protein turnover on a proteome-wide scale. These methods are driven by stable isotope metabolic labeling of cells in culture or in intact animals. This review considers the merits and difficulties of different methods that allow access to proteome dynamics.
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