Journal
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
Volume -, Issue 443, Pages 28-38Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.blo.0000200241.14684.4e
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Funding
- NCRR NIH HHS [C06 RR012538] Funding Source: Medline
- NIAMS NIH HHS [R01 AR041325, AR046121, P30 AR046121, AR043125] Funding Source: Medline
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Bone mineral composition, crystallinity, and bone mineral content of osteoporotic patients are different from those of normal subjects. We review the evidence that these mineralization parameters contribute to the strength (fracture resistance) of bone and the methods that have been used to examine them. A specific example is provided from analysis of biopsies from the Multiple Outcomes in Raloxifene Evaluation trial. For the analyses, randomly selected biopsies from placebo, low-dose, and high-dose groups (n = 5 per group) obtained at time zero and 2 years after treatment were examined by infrared imaging spectroscopy. In all cases, comparable increases in mineral content were found, but there were no significant variations in mineral crystallinity.
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