Journal
JOURNAL OF CLINICAL VIROLOGY
Volume 35, Issue 2, Pages 226-231Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcv.2005.09.016
Keywords
cytomegalovirus; congenital infection; sensorineural hearing loss
Categories
Funding
- NCRR NIH HHS [M01 RR000032, M01 RR00032] Funding Source: Medline
- NIAID NIH HHS [P01 AI043681, P01 AI43681] Funding Source: Medline
- NICHD NIH HHS [P01 HD10699] Funding Source: Medline
- NIDCD NIH HHS [K08 DC00079, R01 DC04163, R01 DC004163] Funding Source: Medline
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Background: The association between congenital cytomegalovirus (CMV) infection and sensorineural hearing loss (SNHL) was first described in 1964. Studies over the past four decades have further described the relationship between congenital CMV infection and SNHL in children. Objectives: This manuscript will review the current knowledge of CMV-related SNHL and summarize the studies completed at the University of Alabama at Birmingham (UAB). Study Design: A review of the series of studies at UAB that has led to a more detailed characterization of hearing loss due to congenital CMV infection. Results: Approximately, 22%-65% of symptomatic and 6%-23% of asymptomatic children will have hearing loss following congenital CMV infection. CMV-related SNHL may be present at birth or occur later in childhood. Variability in the severity of CMV-related hearing loss ranges from unilateral high frequency losses to profound bilateral losses. Conclusions: Congenital CMV infection significantly contributes to SNHL in many infant populations. Although, most children with congenital CMV infection do not develop hearing loss, it is difficult to predict which children with congenital CMV infection will develop hearing loss and, among those who do develop loss, whether or not the loss will continue to deteriorate. (C) 2005 Elsevier B.V. All rights reserved.
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