Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 17, Issue 1, Pages 31-41Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2005.11.011
Keywords
escape behaviour; synapse; development; plasticity; seizure disorder
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Funding
- NINDS NIH HHS [R01-NS044609] Funding Source: Medline
- Wellcome Trust [069710/Z/02/Z] Funding Source: Medline
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Flies escape danger by jumping into the air and flying away. The giant fibre system (GFS) is the neural circuit that mediates this simple behavioural response to Visual stimuli. The sensory signal is received by the giant fibre and relayed to the leg and wing muscle motorneurons. Many of the neurons in the Drosophila GFS are uniquely identifiable and amenable to cell biological, electrophysiological and genetic Studies. Here we review the anatomy and development of this system and highlight its utility for studying many aspects of nervous system biology ranging from neural development and synaptic plasticity to the aetiology of neural disorder. (C) 2005 Elsevier Ltd. All rights reserved.
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