Journal
SEMINARS IN IMMUNOLOGY
Volume 18, Issue 1, Pages 31-39Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2005.11.001
Keywords
B cell development; pre-B cell receptor (pre-BCR); allelic exclusion; V(D)J recombination; transcriptional regulation
Categories
Funding
- NHLBI NIH HHS [HL 48702] Funding Source: Medline
- NIAID NIH HHS [AI 57487, AI 40221] Funding Source: Medline
Ask authors/readers for more resources
Progenitor B lymphocytes that successfully assemble a heavy chain gene encoding an immunoglobulin capable of pairing with surrogate light chain proteins trigger their own further differentiation by signaling via the pre-BCR complex. The pre-BCR signals several rounds of proliferation and, in this expanded population, directs a complex, B cell-specific set of epigenetic changes resulting in allelic exclusion of the heavy chain locus and activation of the light chain loci for V(D)J recombination. (c) 2005 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available