Journal
ACTA OPHTHALMOLOGICA SCANDINAVICA
Volume 84, Issue 1, Pages 62-68Publisher
WILEY
DOI: 10.1111/j.1600-0420.2005.00590.x
Keywords
blood-retinal barrier; endothelin; glaucoma; matrix metalloproteinase; optic disc haemorrhage; vascular dysregulation
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Purpose: To describe a hypothesized relationship between optic disc haemorrhages (ODHs) and primary vascular dysregulation (PVD). Methods: Observational case report of a patient with classical PVD and five bilateral recurrent ODHs Results: The ODHs were superotemporal in the right eye and inferotemporal in the left; the eyes were otherwise normal. Intraocular pressure (IOP) never exceeded 17 mmHg. Visual fields were normal. Increased blood flow resistivity, a reduced blood flow of the extraocular vessels, a low systemic blood pressure, a cold-induced flow stop of the nailfold capillaries, and elevated endothelin-1 plasma levels were found, all confirming the diagnosis of vascular dysregulation. Conclusion: Optic disc haemorrhages may be due to a disturbed blood-retina barrier rather than to a mechanical rupture of the vessel. This barrier dysfunction may occur in the context of PVD.
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