Journal
PHYSIOLOGY
Volume 21, Issue -, Pages 48-60Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00044.2005
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- Medical Research Council [MC_U127088492] Funding Source: Medline
- Wellcome Trust [65565] Funding Source: Medline
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Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1-->AMPK cascade is the signaling pathway responsible for many of these effects.
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