4.4 Article

NnrA is required for full virulence and regulates several Brucella melitensis denitrification genes

Journal

JOURNAL OF BACTERIOLOGY
Volume 188, Issue 4, Pages 1615-1619

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.188.4.1615-1619.2006

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We identified two regulators of denitrification genes in Brucella melitensis 16M: NarR, which regulates the nitrate reductase (nar) operon, and NnrA, which is involved in the expression of the last three reductases of the denitrification pathway (nirK, norB, and nosZ). NnrA is required for virulence in mice and for intracellular resistance to nitric oxide.

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