Journal
IMMUNOLOGICAL REVIEWS
Volume 209, Issue -, Pages 170-175Publisher
WILEY
DOI: 10.1111/j.0105-2896.2006.00356.x
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How equipotent cells develop into complex tissues containing many diverse cell types is still a mystery. However, evidence is accumulating from different tissue systems in multiple organisms that many of the specific receptor families known to regulate cell fate decisions target conserved signaling pathways. A mechanism for preserving specificity in the cellular response that has emerged from these studies is one in which quantitative differences in receptor signaling regulate the cell fate decision. A signal strength model has recently gained support as a means to explain alpha beta/gamma delta lineage commitment. In this review, we compare the alpha beta/gamma delta fate decision with other cell fate decisions that occur outside of the lymphoid system to attain a better picture of the quantitative signaling mechanism for cell fate specification.
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