Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 18, Issue 1, Pages 26-31Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2005.11.005
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM44428] Funding Source: Medline
Ask authors/readers for more resources
Cofilin is a ubiquitous actin-binding factor required for the reorganization of actin filaments in eukaryotes. The dephosphorylation of cofilin enables its actin severing and depolymerizing activity and drives directional cell motility, thus providing a simple phosphoregulatory mechanism for actin reorganization. To date, two cofilin-specific phosphatases have been identified: Slingshot and Chronophin. These cofilin phosphatases are unrelated in sequence and regulatory properties, each potentially providing a unique mechanism for cofilin activation under varying biological circumstances.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available