4.2 Article

Construction of optically active spiroketal by direct aldol reaction

Journal

HETEROCYCLES
Volume 67, Issue 2, Pages 695-+

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-05-S(T)61

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Novel preparation of symmetric spiroketal was developed by the use of direct aldol reaction of alpha-hydroxyacetophenone catalyzed by chiral dinuclear zinc catalyst. The spiroketal was obtained in excellent enantiomeric excess.

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