Journal
NATURE REVIEWS CANCER
Volume 6, Issue 2, Pages 146-155Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1804
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Funding
- NLM NIH HHS [T15 LM007033] Funding Source: Medline
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Oncogenesis and tumour progression are supported by alterations in cell signalling. Using flow cytometry, it is now possible to track and analyse signalling events in individual cancer cells. Data from this type of analysis can be used to create a network map of signalling in each cell and to link specific signalling profiles with clinical outcomes. This form of 'single-cell proteomics' can identify pathways that are activated in therapy-resistant cells and can provide biomarkers for cancer diagnosis and for determining patient prognosis.
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