Journal
BIOPHYSICAL JOURNAL
Volume 90, Issue 3, Pages L21-L23Publisher
CELL PRESS
DOI: 10.1529/biophysj.105.076521
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Funding
- Engineering and Physical Sciences Research Council [EP/C006755/1, GR/S87195/01] Funding Source: researchfish
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Phospholipid vesicles containing ponticulin have been used to form solid supported and tethered bilayer lipid membranes. The ponticulin serves as both a nucleation site for actin polymerization as well as a binding site for F-actin. Studies of F-actin binding to such bilayers have demonstrated the formation of an in vitro actin scaffold. The dissociation constant for the binding of F-actin. laments to a ponticulin-containing tethered bilayer was found to be 11 +/- 5 nM, indicative of high affinity binding.
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