Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 3, Pages 1599-1603Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.80.3.1599-1603.2006
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Funding
- NIAID NIH HHS [T32 AI 07323, AI 36554, R01 AI036554, R37 AI036059, T32 AI007323, AI 36059] Funding Source: Medline
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The host cell activation state impacts the nature of human immunodeficiency virus infection. Activated cells facilitate productive infections; quiescent cells enable the virus to enter a latent state, the major obstacle to viral clearance. We wanted to understand how these differences affected viral gene expression. In quiescent cells activated prior to infection, viral RNA was seen 12 h postinfection; when cells were stimulated postinfection, viral RNA was not seen until 36 h postinfection. Up-regulation of viral RNA in latently infected cells occurred within 2 h poststimulation. This hierarchy also held true for viral protein production. These results may explain the rapid reemergence of viremia following termination of therapy.
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