Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 48, Issue 3, Pages 177-180Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2005.10.007
Keywords
Alzheimer's disease; biomarker; cardiac surgery; cerebral injury; cerebrospinal fluid; cognitive function; cytokine; ELISA; inflammation; interleukin; IL-1 beta; IL-4; IL-6; neuropathology; S100P
Categories
Ask authors/readers for more resources
Recovery from cardiac surgery is marred for many patients by the development of neurological, psychological or cognitive dysfunction. An uncontrolled inflammatory reaction, in response to surgical stress, may be responsible. To confirm this hypothesis, the present study evaluated chances in the levels of cytokines in cerebrospinal fluid after coronary artery bypass grafting. One week post-operatively, the concentration of the pro-inflammatory cytokine interleukin-6 markedly increased; 6 months after surgery, however, its level normalized with an increased concentration of the anti-inflammatory interleukin-4. This suggests that a regulated immune response may participate in developing adverse neurologic events and complications following cardiac interventions, and cytokines in the cerebrospinal fluid may serve as specific biomarkers and predictors of developing cognitive decline after coronary surgery. (C) 2005 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available