Journal
MEDECINE ET MALADIES INFECTIEUSES
Volume 36, Issue 2, Pages 78-91Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.medmal.2005.10.007
Keywords
Pseudomonas aeruginosa; pathogenicity; virulence factors
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Funding
- NHLBI NIH HHS [HL 74005, HL69809] Funding Source: Medline
- NIGMS NIH HHS [GM08440] Funding Source: Medline
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Pseudomonas aeruginosa is an opportunistic pathogen responsible for ventilator-acquired pneumonia, acute lower respiratory tract infections in immunocompromised patients and chronic respiratory infections in cystic fibrosis patients. High incidence, infection severity and increasing resistance characterize P. aeruginosa infections, highlighting the need for new therapeutic options. One such option is to target the many pathogenic mechanisms conferred to P. aeruginosa by its large genome encoding many different virulence factors. This article reviews the pathogenic mechanisms and potential therapies targeting these mechanisms in P. aeruginosa respiratory infections. (c) 2006 Elsevier SAS. All rights reserved.
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