A simple and efficient approach to 1,3-polyols: Application to the synthesis of cryptocarya diacetate

A highly enantio- and stereoselective synthetic strategy for both synand anti-1,3-polyols has been developed. The sequence involves iterative Jacobsen's hydrolytic kinetic resolution (HKR), diastereoselective iodine-induced electrophilic cyclization, and ring-closing metathesis (RCM). This protocol has subsequently been utilized for the synthesis of cryptocarya diacetate, a natural product with broad range of biological activity.