Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 6, Issue 1, Pages 82-88Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2005.09.005
Keywords
-
Categories
Funding
- NIMH NIH HHS [MH61007] Funding Source: Medline
- NINDS NIH HHS [NS45260] Funding Source: Medline
Ask authors/readers for more resources
Ampakines are a structurally diverse family of small molecules that positively modulate alpha-amino-3-hydroxy-5-methyl-4isoxazolepropionic acid (AMPA)-type glutamate receptors, and thereby enhance fast, excitatory transmission throughout the brain. Surprisingly, ampakines have discrete effects on brain activity and behavior. Because their excitatory synaptic targets mediate communication between cortical regions, serve as sites of memory encoding, and regulate the production of growth factors, ampakines have a broad range of potential therapeutic applications. Several of these possibilities have been tested with positive results in preclinical models; preliminary clinical work has also been encouraging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available