Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 44, Issue 2, Pages 595-597Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.44.2.595-597.2006
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The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses.
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