Journal
JOURNAL OF NATURAL PRODUCTS
Volume 69, Issue 2, Pages 185-190Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np058097w
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Six new triterpene saponins, theasaponins A(1) (1), A(2) (2), A(3) (3), F-2 (4), F-2 (5), and F-3 (6), were isolated from the saponin fraction of the seeds of Camellia sinensis. The stereostructures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. Theasaponin A2 (2) showed an inhibitory effect on ethanol-induced gastric mucosal lesions in rats at a dose of 5.0 mg/kg, p.o., and its activity was more potent than that of omeplazole. Structure-activity relationships for theasaponins on ethanol-induced gastroprotective activities may be suggested as follows: (1) the 28-acetyl moiety enhances activity; (2) theasaponins having a 23-aldehyde group exhibit more potent activities than those with a 23-hydroxymethyl group or a 23-methoxycarbonyl group.
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